This study aimed to investigate the use of infrared thermography (IRTPP) as an injury prevention program in professional soccer players during preseason. Twenty-four first division soccer players from Spain participated. The results showed that the implementation of the infrared thermography significantly reduced the number of injuries and days lost due to injuries compared to a conventional injury prevention program (CPP). Players identified as potentially at risk through infrared thermography had fewer musculoskeletal injuries in the thigh, hip, and groin. Overall, the infrared thermography proved to be effective in preventing injuries and reducing their severity and impact on players.